Week 12 action will resume on Monday when the Carolina Panthers travel to Levi’s Stadium to clash with the San Francisco 49ers.
The central storyline of the matchup revolves around Christian McCaffrey, who’ll face Carolina for the first time since departing the franchise in 2022.
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He will take on a Panthers team led by Bryce Young, who led them to an overtime victory over the Atlanta Falcons on Nov. 16. The quarterback threw for a career-high 448 yards and three touchdowns.
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Carolina (6-5) is coming off several notable upsets in recent weeks, and the team is hoping to secure a late playoff push.
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The 49ers (7-4) are the favorites heading into the primetime game. They’ll have a healthier offense than they’ve had all season, with McCaffrey, Brock Purdy, George Kittle, Ricky Pearsall and Jauan Jennings all expected to play.
San Francisco 49ers vs. Carolina Panthers projected starting lineup for Week 12 MNF
San Francisco 49ers projected starting lineup
San Francisco 49ers quarterback Brock Purdy – Source: Imagn
Below is the San Francisco 49ers’ projected to lineup on offense against the Carolina Panthers.
Position
Starter
QB
Brock Purdy
RB
Christian McCaffrey
WR
Jauan Jennings
WR
Ricky Pearsall
WR
Demarcus Robinson
TE
George Kittle
FB
Kyle Juszczyk
LT
Trent Williams
LG
Ben Bartch
C
Jake Brendel
RG
Dominick Puni
RT
Colton McKivitz
Here’s a look at San Francisco’s likely defensive line.
Position
Starter
LDE
Bryce Huff
LDT
Kalia Davis
RDT
Alfred Collins
RDE
Sam Okuayinonu
WLB
Dee Winters
MLB
Curtis Robinson
SLB
Luke Gifford
LCB
Renardo Green
SS
Ji’Ayir Brown
FS
Malik Mustapha
RCB
Deommodore Lenoir
NB
Upton Stout
Let’s look at the 49ers’ special teams projected lineup.
Position
Starter
PK
Matt Gay
P
Thomas Morstead
H
Thomas Morstead
PR
Skyy Moore
KR
Skyy Moore
LS
Jon Weeks
Carolina Panthers projected starting lineup
Carolina Panthers quarterback Bryce Young – Source: Imagn
Below is the Carolina Panthers‘ projected to lineup on offense against the San Francisco 49ers.
Position
Starter
QB
Bryce Young
RB
Rico Dowdle
WR
Tetairoa McMillan
WR
Xavier Legette
WR
Jalen Coker
TE
Ja’Tavion Sanders
LT
Ikem Ekwonu
LG
Damien Lewis
C
Austin Corbett
RG
Chandler Zavala
RT
Taylor Moton
Here’s a look at Carolina’s likely defensive line.
Position
Starter
LDE
Tershawn Wharton
NT
A’Shawn Robinson
RDE
Derrick Brown
WLB
Nic Scourton
LLB
Maema Njongmeta
RLB
Claudin Cherelus
SLB
D.J. Wonnum
LCB
Mike Jackson
SS
Tre’von Moehrig
FS
Nick Scott
RCB
Jaycee Horn
NB
Chau Smith-Wade
Let’s look at the Panters’ special teams projected lineup.
Position
Starter
PK
Ryan Fitzgerald
P
Sam Martin
H
Sam Martin
PR
Trevor Etienne
KR
Trevor Etienne
LS
JJ Jansen
San Francisco 49ers vs. Carolina Panthers depth chart
San Francisco 49ers depth chart
Here is the 49ers’ offensive depth chart.
Position
Starter
2nd
3rd
4th
QB
Brock Purdy
Mac Jones
Kurtis Rourke (out)
–
RB
Christian McCaffrey
Brian Robinson Jr.
Isaac Guerendo
Jordan James
WR
Jauan Jennings
Kendrick Bourne
Brandon Aiyuk (out)
–
WR
Ricky Pearsall
Skyy Moore
Jacob Cowing (IR)
–
WR
Demarcus Robinson
Jordan Watkins
Trent Taylor (IR)
–
TE
George Kittle
Luke Farrell
Jake Tonges
–
FB
Kyle Juszczyk
–
–
–
LT
Trent Williams
Spencer Burford
–
–
LG
Ben Bartch
Spencer Burford
Conner Colby
–
C
Jake Brendel
Matt Hennessy
–
–
RG
Dominick Puni
–
–
–
RT
Colton McKivitz
Austen Pleasants
–
–
San Francisco’s defensive depth chart is listed below.
Position
Starter
2nd
3rd
4th
LDE
Bryce Huff
Keion White
Nick Bosa (IR)
Tarron Jackson (IR)
LDT
Kalia Davis
Kevin Givens
–
–
RDT
Alfred Collins
Jordan Elliott
CJ West
–
RDE
Sam Okuayinonu
Robert Beal Jr. (doubtful)
Clelin Ferrell
Yetur Gross-Matos (IR)
WLB
Dee Winters
Nick Martin
–
–
MLB
Tatum Bethune (out)
Curtis Robinson
Fred Warner (IR)
–
SLB
Luke Gifford
–
–
–
LCB
Renardo Green
Tre Tomlinson
–
–
SS
Ji’Ayir Brown
Jason Pinnock
–
–
FS
Malik Mustapha
Marques Sigle
Siran Neal
–
RCB
Deommodore Lenoir
Darrell Luter Jr.
Jakob Robinson (IR)
–
NB
Upton Stout
Chase Lucas
–
–
Let’s look at the 49ers’ special teams depth chart.
Position
Starter
2nd
3rd
PK
Eddy Pineiro (out)
–
–
P
Thomas Morstead
–
–
H
Thomas Morstead
–
–
PR
Skyy Moore
Jordan Watkins
Jacob Cowing (IR)
KR
Skyy Moore
Isaac Guerendo
–
LS
Jon Weeks
–
–
Carolina Panthers depth chart
Here is the Panthers’ offensive depth chart.
Position
Starter
2nd
3rd
4th
QB
Bryce Young
Andy Dalton
–
–
RB
Rico Dowdle
Chuba Hubbard
Trevor Etienne
Jonathon Brooks (out)
WR
Tetairoa McMillan
Jimmy Horn Jr.
David Moore (IR)
–
WR
Xavier Legette
Brycen Tremayne
–
–
WR
Jalen Coker
Hunter Renfrow
–
–
TE
Ja’Tavion Sanders
Tommy Tremble
Mitchell Evans
James Mitchell
LT
Ikem Ekwonu
Yosh Nijman
–
–
LG
Damien Lewis
Austin Corbett
–
–
C
Cade Mays (out)
Austin Corbett
Nick Samac
–
RG
Chandler Zavala
Jake Curhan
Robert Hunt (IR)
Brady Christiansen (IR)
RT
Taylor Moton
Yosh Nijman
–
–
Carolina’s defensive depth chart is listed below.
Position
Starter
2nd
3rd
LDE
Tershawn Wharton
Bobby Brown III
Popo Aumavae (IR)
NT
A’Shawn Robinson
Bobby Brown III
Cam Jackson
RDE
Derrick Brown
LaBryan Ray
Jared Harrison-Hunte
WLB
Nic Scourton
Trevis Gipson
Patrick Jones II (IR)
LLB
Christian Rozeboom (out)
Maema Njongmeta
Bam Martin-Scott
RLB
Trevin Wallace (out)
Claudin Cherelus
–
SLB
D.J. Wonnum
Princely Umanmielen
Thomas Incoom
LCB
Mike Jackson
Akayleb Evans
Demarri Mathis (IR)
SS
Tre’von Moehrig
Demani Richardson
–
FS
Nick Scott
Lathan Ransom
–
RCB
Jaycee Horn
Corey Thornton
–
NB
Chau Smith-Wade
–
–
Let’s look at the Panthers’ special teams depth chart.
Position
Starter
2nd
3rd
4th
PK
Ryan Fitzgerald
–
–
–
P
Sam Martin
–
–
–
H
Sam Martin
–
–
–
PR
Trevor Etienne
Hunter Renfrow
Jimmy Horn Jr.
–
KR
Trevor Etienne
Chuba Hubbard
Jimmy Horn Jr.
Rico Dowdle
LS
JJ Jansen
–
–
–
How to watch the 49ers vs. Panthers Week 12 MNF game? TV schedule and live stream details
The winner of Monday’s matchup between the Carolina Panthers and the San Francisco 49ers will solidify its position in the NFC playoff picture.
The Week 12 game will start at 8:15 p.m. ET on ESPN, with commentary from Joe Buck (play-by-play) and Troy Aikman (color analyst). Laura Rutledge and Lisa Salters will report from the sidelines.
Fans can also stream the game on ESPN+, NFL+ and FuboTV.
Game info:
Date and time: Monday, Nov. 24 at 8:15 p.m. ET
Location: Levi’s Stadium in Santa Clara, California
TV: ESPN
Announcers: Joe Buck, Troy Aikman, Lisa Salters, Laura Rutledge
Live streaming: FuboTV, Hulu plus Live TV, ESPN+, NFL+
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